Stéphane De Lombaert

Chief Operating Officer & Head of Chemistry at Karos Pharmaceuticals
Pharmaceuticals

Experience

Chief Operating Officer & Head of Chemistry
Karos Pharmaceuticals

January 2015 - Present

Senior Vice President, Chemistry
Karos Pharmaceuticals

July 2010 - Present

Responsible for various aspects of launch, operation and management of start-up biotech. Strategy and implementation of both medicinal chemistry and chemical development activities. Management of collaborative project and CROs. IP Portfolio.


Distinguished Research Fellow
Boehringer Ingelheim Pharmaceuticals

March 2009 - April 2010

Project Leader (LO project)


Director of Medicinal Chemistry
Boehringer Ingelheim Pharmaceuticals

September 2003 - March 2009

Project leader (LO projects), scientific project portfolio management, group leader.


Executive Director of Medicinal Chemistry
Neurogen Corporation

July 1997 - July 2003

Leader of internal and collaborative projects, scientific project portfolio management, group leader.


Staff Scientist
Novartis

April 1990 - July 1997

Project Leader (LO projects) 1991-1997


Education

Colorado State University
Chemistry
1988 - 1989

Prof. Louis Hegedus, Supervisor


University of Virginia
Chemistry
1986 - 1988

Prof. Sidney Hecht, Supervisor


Université catholique de Louvain
Chemistry
1980 - 1985

Prof. Leon Ghosez, Supervisor


Université catholique de Louvain
Chemistry
1976 - 1980

Patents (31)

Chymase inhibitors
Stéphane De Lombaert, Michel Jose Emmanuel
June 5, 2012: 08193214

BENZIMIDAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION (1 worldwide citation)
DE LOMBAERT Stéphane, LIU Weimin, LO Ho Yin, NEMOTO Peter Allen
May 10, 2012: WO/2012/061169

BENZIMIDAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION
CHEN Zhidong, DE LOMBAERT Stéphane, DINES Jonathon Alan, LIU Weimin, LO Ho Yin, LOKE Pui Leng
May 3, 2012: WO/2012/058254

OXADIAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION
BARTOLOZZI Alessandra, BOSANAC Todd, CHEN Zhidong, DE LOMBAERT Stéphane, HUBER John D, LIU Weimin, LO Ho Yin, LOKE Pui Leng, RIETHER Doris, TYE Heather, WU Lifen, ZINDELL Renee M
March 29, 2012: WO/2012/040137

OXADIAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION
BARTOLOZZI Alessandra, BOSANAC Todd, CHEN Zhidong, DE LOMBAERT Stéphane, DINES Jonathon Alan, HUBER John D, LIU Weimin, LOKE Pui Leng, MORWICK Tina Marie, OLAGUE Alan, RIETHER Doris, TYE Heather, WU Lifen, ZINDELL Renee M
March 29, 2012: WO/2012/040139

Chymase Inhibitors
Stéphane De Lombaert, Michel Jose Emmanuel
February 4, 2010: 20100029637-A1

Substituted quinolin-4-ylamine analogues
Rajagopal Bakthavatchalam, Timothy M Caldwell, Bertrand L Chenard, Stéphane De Lombaert, Kevin J Hodgetts
November 19, 2009: 20090286767-A1

Biaryl piperazinyl-pyridine analogues (6 worldwide citation)
Rajagopal Bakthavatchalam, Charles A Blum, Stéphane De Lombaert, Taeyoung Yoon, Xiaozhang Zheng
July 28, 2009: 07566712

Substituted quinolin-4-ylamine analogues (5 worldwide citation)
Rajagopal Bakthavatchalam, Timothy M Caldwell, Bertrand L Chenard, Stéphane De Lombaert, Kevin J Hodgetts
February 10, 2009: 07488740

Substituted (7-pyridyl-4-phenylamino-quinazolin-2-yl)-methanol analogues (2 worldwide citation)
Rajagopal Bakthavatchalam, Charles A Blum, Harry Brielmann, Stéphane De Lombaert, Xiaozhang Zheng
February 12, 2008: 07329664